Porous Polymer Bearing Polyphenolic Organic Building Units as a Chemotherapeutic Agent for Cancer Treatment | Zendy

Piyali Bhanja | Zendy; Snehasis Mishra | Zendy; Krishnendu Manna | Zendy; Krishna Das Saha | Zendy; Asim Bhaumik | Zendy

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Porous Polymer Bearing Polyphenolic Organic Building Units as a Chemotherapeutic Agent for Cancer Treatment

Author(s) -

Piyali Bhanja,

Snehasis Mishra,

Krishnendu Manna,

Krishna Das Saha,

Asim Bhaumik

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01672

Subject(s) - phloroglucinol , annexin , apoptosis , phosphatidylserine , polymer , chemistry , cytotoxicity , cancer cell , membrane , biophysics , cancer , biochemistry , organic chemistry , medicine , biology , in vitro , phospholipid

Cancer is one of the most deadly diseases worldwide. Although several chemotherapeutic agents are available at present for its treatment, they have their own limitations. The main problems of these chemotherapeutic agents are cost involvement and severe life-threatening antagonistic effects. Here, we report a new biodegradable N-rich porous organic polymer methylenedianiline-triformyl phloroglucinol (MDTFP-1) synthesized via a Schiff base condensation reaction between two reactive monomers, that is, 4,4'-methylenedianiline and 2,4,6-triformyl phloroglucinol under inert atmosphere. Because this porous polymer contains polyphenolic building units and has a high Brunauer-Emmett-Teller surface area (283 m 2 g -1 ), it has been explored in the anticancer activity using HCT 116, A549, and MIA PaCa-2 cell lines. We have carried out the flow cytometric assessment using Annexin-V-FITC/PI staining through the exposed level of phosphatidylserine in the outer membrane of cells with MDTFP-1-induced apoptosis. Our results suggested that apoptosis of cells have been enhanced in a time-dependent manner in the presence of this novel porous polymer.

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