Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae | Zendy

Yuelan Li | Zendy; Rongxiu Zhu | Zendy; Jiaozhen Zhang | Zendy; Fei Xie | Zendy; XiaoNing Wang | Zendy; Ke Xu | Zendy; Yanan Qiao | Zendy; ZunTian Zhao | Zendy; HongXiang Lou | Zendy

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Ophiosphaerellins A–I, Polyketide-Derived Compounds from the Endolichenic Fungus Ophiosphaerella korrae

Author(s) -

Yuelan Li,

Rongxiu Zhu,

Jiaozhen Zhang,

Fei Xie,

XiaoNing Wang,

Ke Xu,

Yanan Qiao,

ZunTian Zhao,

HongXiang Lou

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01668

Subject(s) - polyketide , fungus , stereochemistry , biology , computational biology , microbiology and biotechnology , chemistry , botany , biochemistry , biosynthesis , enzyme

Ophiosphaerellins A-I ( 1 - 9 ), the first example of bicyclo[4.1.0]heptenones, as well as their biosynthetic relatives ophiosphaerekorrins A-B ( 10 - 11 ) were isolated from the endolichenic fungus Ophiosphaerella korrae . Biosynthetically, they were derived from the polyketide pathway, and their absolute configurations were determined on the basis of the combination analysis of spectral data, circular dichroism calculations, and single-crystal X-ray diffraction measurement. Preliminary test with thin-layer chromatography bioautography found that this type of compounds showed moderate acetylcholinesterase (AChE) inhibitory effects.

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