Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones | Zendy

Pedireddi Niharika | Zendy; Bokka Venkat Ramulu | Zendy; Gedu Satyanarayana | Zendy

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Brønsted Acid-Mediated Domino One-Pot Dual C–C Bond Formation: Chemoselective Synthesis of Fused Tricyclic Ketones

Author(s) -

Pedireddi Niharika,

Bokka Venkat Ramulu,

Gedu Satyanarayana

Publication year - 2018

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01553

Subject(s) - tricyclic , intramolecular force , domino , chemistry , friedel–crafts reaction , alkylation , acylation , chemoselectivity , combinatorial chemistry , stereochemistry , catalysis , organic chemistry

A chemoselective synthesis of fused novel tricyclic motifs via a facile domino intramolecular cyclization is presented. The strategy enables the formation of dual C-C bond via intramolecular Friedel-Crafts alkylation followed by acylation to accomplish fused tricyclic ketones. Significantly, these fused tricyclic compounds are ubiquitous and constitute major structural cores of natural products.

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