Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its Applications | Zendy

Zhiguo Zhang | Zendy; Xiaolong Gao | Zendy; Haifeng Yu | Zendy; Jingjing Bi | Zendy; Guisheng Zhang | Zendy

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Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its Applications

Author(s) -

Zhiguo Zhang,

Xiaolong Gao,

Haifeng Yu,

Jingjing Bi,

Guisheng Zhang

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01526

Subject(s) - hydroxylation , tandem , oxidative phosphorylation , chemistry , catalysis , organic chemistry , combinatorial chemistry , reaction conditions , cascade reaction , materials science , biochemistry , composite material , enzyme

A tandem oxidative α-hydroxylation/β-acetalization reaction of β-ketoamides was developed in the presence of PIDA and NaOH. This reaction proceeded at 25 °C in the absence of a metal catalyst to provide 2-hydroxy-3,3-dimethoxy- N -substituted butanamides in good to excellent yields from readily available starting materials. The application of this chemistry to the construction of α-hydroxy-β-ketoamides and quinolinones was also described.

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