Improving Antibacterial Activity and Biocompatibility of Bioinspired Electrospinning Silk Fibroin Nanofibers Modified by Graphene Oxide
Author(s) -
Shudong Wang,
Qian Ma,
Ke Wang,
Hongwu Chen
Publication year - 2018
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.7b01210
Subject(s) - biocompatibility , nanofiber , electrospinning , fibroin , materials science , antibacterial activity , nanotechnology , graphene , silk , composite material , polymer , bacteria , biology , metallurgy , genetics
In this article, the silk fibroin (SF)/graphene oxide (GO)-blended nanofibers with one bioinspired nanostructure are fabricated via electrospinning. The morphology, chemical structure, antibacterial activity, and biocompatibility of the blending nanofibers are investigated. The results indicate that GO plays an important role in preparing the distinctive bioinspired structure. The antibacterial activity and in vivo cell culture test demonstrate that blending of GO could improve the antibacterial activity and biocompatibility of SF nanofibers. The blended nanofibers developed in this study may have considerable potential for wound dressing applications.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom