New Application of Old Material: Chinese Traditional Ink for Photothermal Therapy of Metastatic Lymph Nodes | Zendy

Sheng Wang | Zendy; Yongbin Cao | Zendy; Qin Zhang | Zendy; Haibao Peng | Zendy; Lei Liang | Zendy; Qingguo Li | Zendy; Shun Shen | Zendy; Aimaier Tuerdi | Zendy; Ye Xu | Zendy; Sanjun Cai | Zendy; Wuli Yang | Zendy

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New Application of Old Material: Chinese Traditional Ink for Photothermal Therapy of Metastatic Lymph Nodes

Author(s) -

Sheng Wang,

Yongbin Cao,

Qin Zhang,

Haibao Peng,

Lei Liang,

Qingguo Li,

Shun Shen,

Aimaier Tuerdi,

Ye Xu,

Sanjun Cai,

Wuli Yang

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00993

Subject(s) - lymph , photothermal therapy , india ink , medicine , inkwell , biocompatibility , primary tumor , biomedical engineering , pathology , materials science , metastasis , nanotechnology , cancer , metallurgy , composite material , anatomy

Finding a simple and effective strategy to eliminate tumor metastatic lymph nodes is highly desired in clinical tumor treatment. Herein, we reported a Chinese traditional ink (Hu-ink)-based treatment for photothermal therapy (PTT) of tumor metastatic lymph nodes. By simple dilution, stable Chinese traditional ink dispersion was obtained, which presents excellent photothermal effect because of its high absorption in near-infrared (NIR) region. Meanwhile, as revealed by staining and photoacoustic imaging, Hu-ink could transfer to nearby lymph nodes after directly injected into the primary tumors. Under the guidance of dual-modality mapping, the metastatic sentinel lymph nodes could be subsequently eliminated by NIR irradiation. The good biocompatibility of Hu-ink has also been verified by a series of experiments. Therefore, the Hu-ink-based treatment exhibits great potential for PTT of tumor metastatic lymph nodes in future clinical practice.

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