Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2-a]pyridines | Zendy

Vikas Dwivedi | Zendy; Ravi Kumar | Zendy; Kavita Sharma | Zendy; Balasubramanian Sridhar | Zendy; Maddi Sridhar Reddy | Zendy

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Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2-a]pyridines

Author(s) -

Vikas Dwivedi,

Ravi Kumar,

Kavita Sharma,

Balasubramanian Sridhar,

Maddi Sridhar Reddy

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00426

Subject(s) - regioselectivity , intermolecular force , chemistry , aminopyridines , structural isomer , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , molecule

A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo[1,2- a ]pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu(OTf) 2 -mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3.

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