Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative | Zendy

Ismael Raitz | Zendy; Roberto Yoshio de Souza Filho | Zendy; Lorena P. de Andrade | Zendy; José R. Corrêa | Zendy; Brenno A. D. Neto | Zendy; Ronaldo A. Pilli | Zendy

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Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative

Author(s) -

Ismael Raitz,

Roberto Yoshio de Souza Filho,

Lorena P. de Andrade,

José R. Corrêa,

Brenno A. D. Neto,

Ronaldo A. Pilli

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00416

Subject(s) - fluorescence , fluorophore , mitochondrion , cytoplasm , derivative (finance) , subcellular localization , chemistry , membrane , biophysics , transmembrane protein , cell , microbiology and biotechnology , biochemistry , biology , receptor , physics , quantum mechanics , financial economics , economics

A fluorescent 2,1,3-benzothiadiazole-containing goniothalamin derivative, BTD-GTN ( 1 ), has been synthesized and successfully tested in bioimaging experiments in live cells. The fluorescent compound proved to be capable of transposing the cell membranes, indicating its subcellular localization. The use of the benzothiadiazole core as the fluorophore revealed the favored localization of the GTN analogue 1 in the cytoplasm of live cells, preferentially in the mitochondria, in line with previous results that indicated the loss of mitochondrial transmembrane potential upon treatment with GTN. The results described herein highlight the potential of the BTD-GTN hybrid structures for future studies regarding the cellular mechanism of action of this family of compounds.

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