Quantitative Photodeprotection Assessment of Caged Resveratrol by Fluorescence Measurement | Zendy

Shin Hikage | Zendy; Yasuhiro Nishiyama | Zendy; Yasuo Sasaki | Zendy; Hiroki Tanimoto | Zendy; Tsumoru Morimoto | Zendy; Kiyomi Kakiuchi | Zendy

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Quantitative Photodeprotection Assessment of Caged Resveratrol by Fluorescence Measurement

Author(s) -

Shin Hikage,

Yasuhiro Nishiyama,

Yasuo Sasaki,

Hiroki Tanimoto,

Tsumoru Morimoto,

Kiyomi Kakiuchi

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00250

Subject(s) - resveratrol , fluorescence , chemistry , molecule , biophysics , photochemistry , combinatorial chemistry , biochemistry , organic chemistry , biology , physics , quantum mechanics

For monitoring the regenerated bioactivity of a masked bioactive compound, resveratrol (a luciferase inhibitor) was selected to target such a compound. Caged resveratrol, masked by thiochromone-type photolabile-protecting groups was synthesized in the study. Each caged resveratrol showed lower bioactivity when compared to that shown by the original molecule. After photoirradiation, the original bioactivity was found to be regenerated. Furthermore, the fluorescent compound derived from the thiochromone-type photolabile-protecting groups was generated simultaneously. A linear correlation was observed between the regenerated bioactivity and generated fluorescence intensity. Thus, we quantitatively monitored the recovered bioactivity successfully by measuring the fluorescence.

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