Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives | Zendy

Mia Imanishi | Zendy; Motohiro Sonoda | Zendy; Hironari Miyazato | Zendy; Keiichiro Sugimoto | Zendy; Mitsugu Akagawa | Zendy; Shinji Tanimori | Zendy

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Sequential Synthesis, Olfactory Properties, and Biological Activity of Quinoxaline Derivatives

Author(s) -

Mia Imanishi,

Motohiro Sonoda,

Hironari Miyazato,

Keiichiro Sugimoto,

Mitsugu Akagawa,

Shinji Tanimori

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00124

Subject(s) - quinoxaline , chemistry , inhibitory postsynaptic potential , combinatorial chemistry , amino acid , biological activity , stereochemistry , biochemistry , organic chemistry , in vitro , biology , neuroscience

A simple, practical, and rapid access to quinoxalin-2-ones 1 , 1,2,3,4-tetrahydroquinoxalines 2 , quinoxalines 3 , and quinoxalin-2(1 H )-ones 4 has been achieved, based on the copper-catalyzed quinoxalinone formation of 2-haloanilines and amino acids followed by their reduction and oxidation. The olfactory properties and lipid accumulation inhibitory activity in cultured hepatocytes of the quinoxaline derivatives were also evaluated.

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