Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2-a]pyrimidines and Pyrazolo[1,5-a]pyrimidines | Zendy

Siva K. Reddy Kotla | Zendy; Jaya Kishore Vandavasi | Zendy; JehJeng Wang | Zendy; Keykavous Parang | Zendy; Rakesh K. Tiwari | Zendy

Open Access

Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2-a]pyrimidines and Pyrazolo[1,5-a]pyrimidines

Author(s) -

Siva K. Reddy Kotla,

Jaya Kishore Vandavasi,

JehJeng Wang,

Keykavous Parang,

Rakesh K. Tiwari

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.6b00417

Subject(s) - intramolecular force , palladium , catalysis , chemistry , substrate (aquarium) , combinatorial chemistry , coupling reaction , scope (computer science) , coupling (piping) , stereochemistry , organic chemistry , materials science , computer science , biology , ecology , metallurgy , programming language

A palladium-catalyzed intramolecular dehydrogenative coupling reaction was developed for the synthesis of fused imidazo[1,2- a ]pyrimidines and pyrazolo[1,5- a ]pyrimidines. The developed protocol provides a practical approach for the synthesis of biologically important substituted pyrimidines from easily available substrates, with a broad substrate scope under mild reaction conditions.

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