Open AccessMammalian and Fish Gelatin Methacryloyl–Alginate Interpenetrating Polymer Network Hydrogels for Tissue Engineering
Author(s) -
Chen Ma,
Jongkeun Choi,
Yong-Seok Jang,
SeoYoung Kim,
TaeSung Bae,
Yu-Kyoung Kim,
JuMi Park,
Minho Lee
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c01806
Subject(s) - self healing hydrogels , gelatin , interpenetrating polymer network , tissue engineering , swelling , materials science , biomaterial , polymer , biomedical engineering , chemical engineering , polymer chemistry , chemistry , nanotechnology , composite material , biochemistry , engineering , medicine
Gelatin methacryloyl (GelMA) has been widely studied as a biomaterial for tissue engineering. Most studies focus on mammalian gelatin, but certain factors, such as mammalian diseases and diet restrictions, limit the use of mammalian gelatin. Thus, fish gelatin has received much attention as a substitute material in recent years. To develop a broadly applicable hydrogel with excellent properties, an interpenetrating polymer network (IPN) hydrogel was synthesized, since IPN hydrogels consist of at least two different hydrogel components to combine their advantages. In this study, we prepared GelMA using type A and fish gelatin and then synthesized IPN hydrogels using GelMA with alginate. GelMA single-network hydrogels were used as a control group. The favorable mechanical properties of type A and fish hydrogels improved after the synthesis of the IPN hydrogels. Type A and fish IPN hydrogels showed different mechanical properties (mechanical strength, swelling ratio, and degradation rate) and different cross-sectional morphologies, since the degree of mechanical enhancement in fish IPN hydrogels was less than that in type A; however, the cell biocompatibilities were not significantly different. Therefore, these findings could serve as a reference for future studies when selecting GelMA as a biological material for tissue engineering.