Open AccessDulaglutide Alleviates LPS-Induced Injury in Cardiomyocytes
Author(s) -
Rijun Wang,
Ning Wang,
Yuping Han,
Jiyao Xu,
Zhou Xu
Publication year - 2021
Publication title -
acs omega
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.0c06326
Subject(s) - oxidative stress , western blot , pharmacology , nitric oxide synthase , nadph oxidase , tumor necrosis factor alpha , nitric oxide , reactive oxygen species , chemistry , microbiology and biotechnology , medicine , immunology , biology , biochemistry , gene
Sepsis is a severe infection-induced disease with multiple organ failure, and sepsis-induced cardiomyopathy is a fatal condition. Inflammatory response and oxidative stress are reported to be involved in the development of sepsis-induced cardiomyopathy. Dulaglutide is a novel antidiabetic agent that is currently reported to exert an anti-inflammatory effect. The present study aims to explore the potential protective property of dulaglutide on lipopolysaccharide (LPS)-induced injury on cardiomyocytes.