Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier | Zendy

Zhen Shi | Zendy; Yazhen Wang | Zendy; Tianyuan Xiao | Zendy; Shaobo Dong | Zendy; Tianyu Lan | Zendy

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Preparation and Thermal Decomposition Kinetics of a New Type of a Magnetic Targeting Drug Carrier

Author(s) -

Zhen Shi,

Yazhen Wang,

Tianyuan Xiao,

Shaobo Dong,

Tianyu Lan

Publication year - 2021

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c06075

Subject(s) - thermal decomposition , polyvinyl alcohol , differential scanning calorimetry , materials science , thermal stability , kinetics , chemical engineering , isothermal process , decomposition , enthalpy , drug carrier , chemistry , polymer chemistry , drug delivery , organic chemistry , nanotechnology , composite material , thermodynamics , physics , quantum mechanics , engineering

We have designed a new magnetic targeting drug carrier Fe 3 O 4 -PVA with a core of triiron tetroxide (Fe 3 O 4 ) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe 3 O 4 . With adriamycin hydrochloride as a model drug, this study goes on to measure the drug carrier performance of Fe 3 O 4 -PVA. In addition, the thermal stability and enthalpy of thermal decomposition of Fe 3 O 4 -PVA were measured using a differential scanning calorimeter with a non-isothermal decomposition method. The kinetics of thermal decomposition of Fe 3 O 4 -PVA were also investigated. Over the course of this study, it was determined that the resulting drug carrier Fe 3 O 4 -PVA exhibited high drug loading levels and excellent release levels.

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