Open Access1,4-Dideoxy-1,4-imino-d -arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
Author(s) -
Marianne B. Haarr,
Óscar López,
Ljupcho Pejov,
José G. FernándezBolaños,
Emil Lindbäck,
Magne O. Sydnes
Publication year - 2020
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.0c02466
Subject(s) - moiety , hydrazide , chemistry , imide , stereochemistry , biochemistry , organic chemistry
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges ( K i values ranging from 0.23 to 1.4 μM).
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