Influence of Oxidation Degree of Graphene Oxide on Its Nuclear Relaxivity and Contrast in MRI | Zendy

Zinia Mohanta | Zendy; Sumana K. Gaonkar | Zendy; Manoj Kumar | Zendy; Jitender Saini | Zendy; Vivek Tiwari | Zendy; Chandan Srivastava | Zendy; Hanudatta S. Atreya | Zendy

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Influence of Oxidation Degree of Graphene Oxide on Its Nuclear Relaxivity and Contrast in MRI

Author(s) -

Zinia Mohanta,

Sumana K. Gaonkar,

Manoj Kumar,

Jitender Saini,

Vivek Tiwari,

Chandan Srivastava,

Hanudatta S. Atreya

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c02220

Subject(s) - graphene , paramagnetism , oxide , nuclear magnetic resonance , materials science , magnetic resonance imaging , relaxometry , relaxation (psychology) , ion , nuclear magnetic resonance spectroscopy , contrast enhancement , chemistry , nanotechnology , condensed matter physics , spin echo , physics , radiology , organic chemistry , medicine , psychology , social psychology , metallurgy

Graphene oxide (GO) serves as a versatile platform for various applications, with the oxygen content of GO playing an important role in governing its properties. In the present study, different GO types covering a wide range of oxidation degree were prepared using our newly developed two-step method involving ball milling of graphite followed by its oxidation to GO. In addition to the variations in their physicochemical properties, the different GO types exhibited differences in proton relaxivity due to their paramagnetic nature. Nuclear magnetic resonance spectroscopy studies showed that the degree of oxidation of GO perturbs its nuclear relaxation properties and, together with intercalated Mn 2+ ions, provides large contrast variation in magnetic resonance imaging (MRI). The study for the first time reveals that the surface chemistry of GO affects its relaxivity and opens up new avenues for developing tunable GO-based contrast agents in magnetic resonance imaging for diagnostics and therapies.

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