Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation | Zendy

Yuriy A. Kvashnin | Zendy; Egor V. Verbitskiy | Zendy; Ekaterina F. Zhilina | Zendy; Gennady L. Rusinov | Zendy; О. Н. Чупахин | Zendy; Valery N. Charushin | Zendy

Open Access

Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation

Author(s) -

Yuriy A. Kvashnin,

Egor V. Verbitskiy,

Ekaterina F. Zhilina,

Gennady L. Rusinov,

О. Н. Чупахин,

Valery N. Charushin

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c01945

Subject(s) - intramolecular force , palladium , annulation , domino , catalysis , chemistry , oxidative phosphorylation , aryl , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , alkyl

A convenient approach to [1,2,5]oxadiazolo[3',4':5,6]pyrazino[2,3- b ]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald-Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.

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