Synthesis and Comparative Evaluation of Photoswitchable Magnetic Resonance Imaging Contrast Agents | Zendy

Mingchun Gao | Zendy; Bowen Shen | Zendy; Junhan Zhou | Zendy; Rohan Kapre | Zendy; Angelique Y. Louie | Zendy; Jared T. Shaw | Zendy

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Synthesis and Comparative Evaluation of Photoswitchable Magnetic Resonance Imaging Contrast Agents

Author(s) -

Mingchun Gao,

Bowen Shen,

Junhan Zhou,

Rohan Kapre,

Angelique Y. Louie,

Jared T. Shaw

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c01534

Subject(s) - spiropyran , merocyanine , photochromism , gadolinium , chemistry , photochemistry , substituent , nuclear magnetic resonance , magnetic resonance imaging , visible spectrum , materials science , stereochemistry , organic chemistry , optoelectronics , physics , medicine , radiology

A series of spiropyran (SP)-based magnetic resonance imaging (MRI) contrast agents have been synthesized and evaluated for changes in relaxivity resulting from irradiation with visible light. Both electron-donating and electron-withdrawing substituents were appended to the SP ring in order to study the electronic effects on the photochromic and relaxivity properties of these photoswitchable MRI contrast agents. Photoswitches lacking an electron-withdrawing substituent isomerize readily between the merocyanine and SP forms, while the addition of a nitro group prevents this process. Complexes capable of isomerizing were demonstrated to effect a change in the relaxivity of the appended gadolinium complex.

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