Antibody-Based Receptor Targeting Using an Fc-Binding Peptide-Dodecaborate Conjugate and Macropinocytosis Induction for Boron Neutron Capture Therapy | Zendy

Ikuhiko Nakase | Zendy; Naoki Takemura | Zendy; Yuriko Ito Sakai | Zendy; Shiori Hirase | Zendy; Miki Ishimura | Zendy; Tomoka TakataniNakase | Zendy; Yoshihide Hattori | Zendy; Mitsunori Kirihata | Zendy

Open Access

Antibody-Based Receptor Targeting Using an Fc-Binding Peptide-Dodecaborate Conjugate and Macropinocytosis Induction for Boron Neutron Capture Therapy

Author(s) -

Ikuhiko Nakase,

Naoki Takemura,

Yuriko Ito Sakai,

Shiori Hirase,

Miki Ishimura,

Tomoka TakataniNakase,

Yoshihide Hattori,

Mitsunori Kirihata

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c01377

Subject(s) - cancer research , conjugate , antibody , cancer , neutron capture , cancer cell , chemistry , boron , medicine , immunology , mathematical analysis , mathematics , organic chemistry

Boron neutron capture therapy (BNCT) is a radiation method used for cancer therapy. Cellular uptake of boron-10 ( 10 B) atoms induces cancer cell death by the generation of alpha particles and recoiling lithium-7 ( 7 Li) nuclei when the cells are irradiated with low-energy thermal neutrons. Current BNCT technology shows effective therapeutic benefits in refractory cancers such as brain tumors and head and neck cancers. However, improvements to cancer targeting and the cellular uptake efficacy of the boron compounds and the expansion of the diseases treatable by BNCT are highly desirable. In this research, we aimed to develop an antibody-based drug delivery method for BNCT through the use of the Z33 peptide, which shows specific recognition of and interaction with the Fc domain of human IgG, for on-demand receptor targeting. In addition, we determined with an in vitro assay that macropinocytosis induction during antibody-based drug delivery is crucial for the biological activity of BNCT.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research