Anti-inflammatory Withanolides from Physalis minima | Zendy

Jiangping Wu | Zendy; Tao Zhang | Zendy; Meng Yu | Zendy; HongMei Jia | Zendy; Hongwu Zhang | Zendy; Qiongming Xu | Zendy; YuCheng Gu | Zendy; ZhongMei Zou | Zendy

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Anti-inflammatory Withanolides from Physalis minima

Author(s) -

Jiangping Wu,

Tao Zhang,

Meng Yu,

HongMei Jia,

Hongwu Zhang,

Qiongming Xu,

YuCheng Gu,

ZhongMei Zou

Publication year - 2020

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c00467

Subject(s) - chemistry , nitric oxide , physalis , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , ic50 , in vitro , biochemistry , botany , organic chemistry , biology

Five new withanolides ( 1-5 ) along with five known ones ( 6-10 ) were isolated from the whole plants of Physalis minima Linn. The chemical structures of the new compounds were identified as (20 S ,22 R ) 15 a -acetoxy-5β,6β-epoxy-4β,14 a ,28-trihydroxy-3β-methoxy-1-oxowitha-16,24-dienolide ( 1 ), (20 S ,22 R ) 15 a -acetoxy-5β,6β-epoxy-3β,4β,14β,17β,20β-pentahydroxy-1-oxowitha-24-enolide ( 2 ), (20 R ,22 R ) 15α-acetoxy-4β,5α,6β,14α,20β-pentahydroxy-1-oxowitha-2,24-dienolide ( 3 ), (20 R ,22 R ) 15α-acetoxy-5α,6β,14α,20β-tetrahydroxy-1-oxowitha-2,24-dienolide ( 4 ), and (20 S ,22 R ) 5α,6β,14β-trihydroxy-1,15-dioxowitha-2,16,24-trienolide ( 5 ) on the basis of integration combining IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR analyses. Biologically, compounds ( 1-10 ) were subjected to evaluate their anti-inflammatory activities via inhibiting nitric oxide production in lipopolysaccharide-stimulated murine RAW 264.7 cells in vitro . The activity screening indicated that all of the compounds showed a moderate inhibitory effect against nitric oxide production with IC 50 values of 23.53-66.28 μM.

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