5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction–Extraction System Using a Microreactor and Extractor | Zendy

Yosuke Muranaka | Zendy; Kenta Matsubara | Zendy; Taisuke Maki | Zendy; Shusaku Asano | Zendy; Hiroyuki Nakagawa | Zendy; Kazuhiro Mae | Zendy

Open Access

5-Hydroxymethylfurfural Synthesis from Monosaccharides by a Biphasic Reaction–Extraction System Using a Microreactor and Extractor

Author(s) -

Yosuke Muranaka,

Kenta Matsubara,

Taisuke Maki,

Shusaku Asano,

Hiroyuki Nakagawa,

Kazuhiro Mae

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c00399

Subject(s) - microreactor , chemistry , extraction (chemistry) , yield (engineering) , monosaccharide , chromatography , isomerization , catalysis , fructose , organic chemistry , materials science , metallurgy

5-Hydroxymethylfurfural (HMF) was synthesized from monosaccharides by a biphasic reaction system using a microreactor. The biphasic reaction system realized an immediate extraction and stabilization of product HMF, which further degrades under the reaction conditions. Segmented flow was utilized for an efficient reaction-extraction tool. The effect of extraction ability was evaluated based on the extraction phase/reaction phase partition coefficient of HMF. A Lewis acid catalyst was introduced to overcome the obstacle of the reaction, which was clarified as the isomerization of glucose to fructose, and improved the HMF yield to 85 mol % under the condition of T = 180 °C and τ = 47 min. The recovery of the product HMF was also examined using a constructed microextraction system, and HMF was selectively recovered from the extraction phase.

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