Open AccessDevelopment of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain
Author(s) -
Santo Previti,
Roberta Ettari,
Elsa Calcaterra,
Carla Di Chio,
R Ravichandran,
Collin Zimmer,
Stefan Hammerschmidt,
Annika Wagner,
Marta Bogacz,
Sandro Cosconati,
Tanja Schirmeister,
Maria Zappalà
Publication year - 2022
Publication title -
acs medicinal chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 66
ISSN - 1948-5875
DOI - 10.1021/acsmedchemlett.2c00084
Subject(s) - urea , trypanosoma brucei , antiparasitic , trypanosoma brucei rhodesiense , michael reaction , african trypanosomiasis , protease , trypanosoma , stereochemistry , cysteine , chemistry , structure–activity relationship , cysteine protease , combinatorial chemistry , biochemistry , biology , pharmacology , trypanosomiasis , in vitro , virology , medicine , enzyme , pathology , gene , catalysis