Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate–Carbohydrate Interactions | Zendy

Sangho Won | Zendy; Steven A. Hindmarsh | Zendy; Matthew I. Gibson | Zendy

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Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate–Carbohydrate Interactions

Author(s) -

Sangho Won,

Steven A. Hindmarsh,

Matthew I. Gibson

Publication year - 2018

Publication title -

acs macro letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.966

H-Index - 92

ISSN - 2161-1653

DOI - 10.1021/acsmacrolett.7b00891

Subject(s) - carbohydrate , glycan , lactose , macromolecule , chemistry , polymer , nanotechnology , biochemistry , biophysics , materials science , organic chemistry , biology , glycoprotein

Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer "gate" enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate-carbohydrate interactions are investigated using this tool.

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