Open AccessAntimicrobial Susceptibility Testing of Antimicrobial Peptides Requires New and Standardized Testing Structures
Author(s) -
Marita Meurer,
Deborah A. O′Neil,
Emma Lovie,
Laura W. Simpson,
Marcelo Der Torossian Torres,
César de la Fuente-Núñez,
Alfredo M. Ángeles-Boza,
Christin Kleinsorgen,
Derry K. Mercer,
Maren von KöckritzBlickwede
Publication year - 2021
Publication title -
acs infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.324
H-Index - 39
ISSN - 2373-8227
DOI - 10.1021/acsinfecdis.1c00210
Subject(s) - standardization , antimicrobial peptides , relevance (law) , antimicrobial , test (biology) , clinical microbiology , medicine , computer science , microbiology and biotechnology , biology , political science , paleontology , law , operating system
The need for optimized as well as standardized test systems of novel antimicrobial peptides (AMPs) was discussed by experts in the field at the International Meeting on Antimicrobial Peptides (IMAP) 2017 and the 2019 Gordon Research Conference (GRC) on Antimicrobial Peptides, and a survey related to this topic was circulated to participants to collate opinions. The survey included questions ranging from the relevance of susceptibility testing for understanding the mode of action of AMPs, to the importance of optimization and a degree of standardization of test methods and their clinical relevance. Based on the survey results, suggestions for future improvements in the research field are made.