Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments | Zendy

Sina Haftchenary | Zendy; Shawn D. Nelson | Zendy; Laura Furst | Zendy; Sivaraman Dandapani | Zendy; Steven Ferrara | Zendy; Žarko Bošković | Zendy; Samuel Figueroa Lazú | Zendy; Adrian M. Guerrero | Zendy; Juan Carlos Serrano | Zendy; DeMarcus K. Crews | Zendy; Cristina Brackeen | Zendy; Jeffrey Mowat | Zendy; Thomas Brumby | Zendy; Marcus Bauser | Zendy; Stuart L. Schreiber | Zendy; Andrew J. Phillips | Zendy

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Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Author(s) -

Sina Haftchenary,

Shawn D. Nelson,

Laura Furst,

Sivaraman Dandapani,

Steven Ferrara,

Žarko Bošković,

Samuel Figueroa Lazú,

Adrian M. Guerrero,

Juan Carlos Serrano,

DeMarcus K. Crews,

Cristina Brackeen,

Jeffrey Mowat,

Thomas Brumby,

Marcus Bauser,

Stuart L. Schreiber,

Andrew J. Phillips

Publication year - 2016

Publication title -

acs combinatorial science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.928

H-Index - 81

eISSN - 2156-8952

pISSN - 2156-8944

DOI - 10.1021/acscombsci.6b00050

Subject(s) - chemistry , alcohol , combinatorial chemistry , stereochemistry , organic chemistry

Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).

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