Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy | Zendy

Milad Ashrafizadeh | Zendy; Ali Zarrabi | Zendy; Kiavash Hushmandi | Zendy; Farid Hashemi | Zendy; Ebrahim Rahmani Moghadam | Zendy; Mehdi Raei | Zendy; Mahshad Kalantari | Zendy; Shima Tavakol | Zendy; Reza Mohammadinejad | Zendy; Masoud Najafi | Zendy; Franklin R. Tay | Zendy; Pooyan Makvandi | Zendy

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Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

Author(s) -

Milad Ashrafizadeh,

Ali Zarrabi,

Kiavash Hushmandi,

Farid Hashemi,

Ebrahim Rahmani Moghadam,

Mehdi Raei,

Mahshad Kalantari,

Shima Tavakol,

Reza Mohammadinejad,

Masoud Najafi,

Franklin R. Tay,

Pooyan Makvandi

Publication year - 2020

Publication title -

acs combinatorial science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.928

H-Index - 81

eISSN - 2156-8952

pISSN - 2156-8944

DOI - 10.1021/acscombsci.0c00099

Subject(s) - chemistry , nanocarriers , camptothecin , curcumin , small interfering rna , paclitaxel , pharmacology , cancer therapy , docetaxel , doxorubicin , cancer , etoposide , drug delivery , cancer research , chemotherapy , rna , medicine , gene , biochemistry , organic chemistry

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, co-delivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.

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