Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions | Zendy

Álvaro L. GarciaGarcía | Zendy; Mariano SoizaReilly | Zendy

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Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions

Author(s) -

Álvaro L. GarciaGarcía,

Mariano SoizaReilly

Publication year - 2018

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.8b00534

Subject(s) - neuroscience , serotonin , punishment (psychology) , psychology , biological neural network , neuronal circuits , cognitive psychology , biology , developmental psychology , receptor , biochemistry

Pioneering work showed that serotonin (5-HT) neurons have the unique capacity to engage in different and opposed aspects of motivated behaviors such as reward and punishment responses. These findings provided strong evidence about the functional heterogeneity of 5-HT neurons, and their possible engagement in multiple and behaviorally distinct neural subsystems. A recent study provides further compelling evidence supporting this notion, in which two ascending 5-HT circuits modulate opposed aspects of motivated behaviors.

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