Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice | Zendy

Daniela Neuhofer | Zendy; Olivier Lassalle | Zendy; Olivier J. Manzoni | Zendy

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Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice

Author(s) -

Daniela Neuhofer,

Olivier Lassalle,

Olivier J. Manzoni

Publication year - 2018

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.7b00398

Subject(s) - nucleus accumbens , neuroscience , synaptic plasticity , muscarinic acetylcholine receptor , excitatory postsynaptic potential , muscarinic acetylcholine receptor m4 , long term potentiation , long term depression , metabotropic glutamate receptor , postsynaptic potential , chemistry , biology , nmda receptor , receptor , ampa receptor , dopamine , inhibitory postsynaptic potential , biochemistry

We investigated how metabotropic acetylcholine receptors control excitatory synaptic plasticity in the mouse nucleus accumbens core. Pharmacological and genetic approaches revealed that M 1 mAChRs (muscarinic acetylcholine receptors) trigger multiple and interacting forms of synaptic plasticity. As previously described in the dorsal striatum, moderate pharmacological activation of M 1 mAChR potentiated postsynaptic NMDARs. The M 1 -potentiation of NMDAR masked a previously unknown coincident TRPV1-mediated long-term depression (LTD). In addition, strong pharmacological activation of M 1 mAChR induced canonical retrograde LTD, mediated by presynaptic CB1R. In the fmr1-/y mouse model of Fragile X, we found that CB1R but not TRPV1 M 1 -LTD was impaired. Finally, pharmacological blockade of the degradation of anandamide and 2-arachidonylglycerol, the two principal endocannabinoids restored fmr1-/y LTD to wild-type levels. These findings shed new light on the complex influence of acetylcholine on excitatory synapses in the nucleus accumbens core and identify new substrates of the synaptic deficits of Fragile X.

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