Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors | Zendy

Carine Bécamel | Zendy; Coralie Berthoux | Zendy; Alexander Barre | Zendy; Philippe Marin | Zendy

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Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Author(s) -

Carine Bécamel,

Coralie Berthoux,

Alexander Barre,

Philippe Marin

Publication year - 2017

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.6b00409

Subject(s) - glutamatergic , neuroscience , 5 ht2a receptor , neurotransmission , excitatory postsynaptic potential , serotonin , postsynaptic potential , receptor , 5 ht receptor , biology , glutamate receptor , inhibitory postsynaptic potential , biochemistry

The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.

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