New Modalities in Drug Therapy: Modifying Ongoing Chemical Conversations in the Brain | Zendy

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New Modalities in Drug Therapy: Modifying Ongoing Chemical Conversations in the Brain

Author(s) -

Terry Kenakin

Publication year - 2016

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.6b00330

Subject(s) - agonism , neuroscience , allosteric regulation , modalities , chemical space , drug , drug discovery , psychology , functional selectivity , therapeutic modalities , pharmacology , receptor , g protein coupled receptor , medicine , bioinformatics , biology , political science , social science , sociology , politics , law

The modification of ongoing chemical signaling in the brain through allosteric modification of seven transmembrane receptors offers a wealth of diverse beneficial outcomes in drug therapy. Specifically, biased agonism can emphasize beneficial signals and de-emphasize harmful signals thus increasing the effectiveness of agonists and opening up new vistas for previously precluded drug targets. In addition, the modification of natural agonism through positive and negative allostery can provide useful rejuvenation of failing systems.

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