Luciferins Behave Like Drugs | Zendy

David M. Mofford | Zendy; Stephen C. Miller | Zendy

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Luciferins Behave Like Drugs

Author(s) -

David M. Mofford,

Stephen C. Miller

Publication year - 2015

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.5b00195

Subject(s) - bioluminescence , luciferase , luciferin , luciferases , firefly protocol , chemistry , substrate specificity , biophysics , biochemistry , neuroscience , nanotechnology , biology , enzyme , materials science , zoology , transfection , gene

The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments. In this Viewpoint, we discuss bioluminescent imaging probes for the enzyme fatty acid amide hydrolase (FAAH) and the broader implications for optical imaging and drug delivery in the brain.

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