Serotonin: A New Hope in Alzheimer’s Disease? | Zendy

Sylvie Claeysen | Zendy; Joël Bockaert | Zendy; Patrizia Giani | Zendy

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Serotonin: A New Hope in Alzheimer’s Disease?

Author(s) -

Sylvie Claeysen,

Joël Bockaert,

Patrizia Giani

Publication year - 2015

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.5b00135

Subject(s) - serotonin , dementia , neuroscience , disease , alzheimer's disease , medicine , psychology , bioinformatics , biology , receptor

Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.

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