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Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical evaluation of a new CB1R specific radiotracer, [ 18 F]FPATPP. [ 18 F]FPATPP was produced with 16.7 ± 5.7% decay-corrected radiochemical yield and &gt;95 GBq/μmol molar activity. The tracer showed high stability, low defluorination, and high specific binding to CB1Rs in mouse brain.

Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP

Ruthenium-Mediated ¹⁸F-Fluorination and Preclinical Evaluation of a New CB₁ Receptor Imaging Agent [¹⁸F]FPATPP