Novel Furan-2-yl-1H-pyrazoles Possess Inhibitory Activity against α-Synuclein Aggregation | Zendy

Philip Ryan | Zendy; Mingming Xu | Zendy; Kousar Jahan | Zendy; Andrew K. Davey | Zendy; Prasad V. Bharatam | Zendy; Shailendra AnoopkumarDukie | Zendy; Michael Kassiou | Zendy; George D. Mellick | Zendy; Santosh Rudrawar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Novel Furan-2-yl-1H-pyrazoles Possess Inhibitory Activity against α-Synuclein Aggregation

Author(s) -

Philip Ryan,

Mingming Xu,

Kousar Jahan,

Andrew K. Davey,

Prasad V. Bharatam,

Shailendra AnoopkumarDukie,

Michael Kassiou,

George D. Mellick,

Santosh Rudrawar

Publication year - 2020

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.0c00252

Subject(s) - furan , chemistry , in vitro , pharmacology , stereochemistry , inhibitory postsynaptic potential , structure–activity relationship , biochemistry , biology , neuroscience , organic chemistry

A series of novel furan-2-yl-1 H -pyrazoles and their chemical precursors were synthesized and evaluated for their effectiveness at disrupting α-synuclein (α-syn) aggregation in vitro . The compounds were found to inhibit α-syn aggregation with efficacy comparable to the promising drug candidate anle138b. The results of this study indicate that compounds 8b , 8l , and 9f may qualify as secondary leads for the structure-activity relationship studies aimed to identify the suitable compounds for improving the modulatory activity targeted at α-syn self-assembly related to Parkinson's disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research