Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia | Zendy

Abolfazl Torabi | Zendy; Esmaeil Mohammadbagheri | Zendy; Nader Akbari Dilmaghani | Zendy; AmirHossein Bayat | Zendy; Mobina Fathi | Zendy; Kimia Vakili | Zendy; Rafieh Alizadeh | Zendy; Omidvar Rezaeimirghaed | Zendy; Mohammadreza Hajiesmaeili | Zendy; Mahtab Ramezani | Zendy; Leila Simani | Zendy; Abbas Aliaghaei | Zendy

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Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia

Author(s) -

Abolfazl Torabi,

Esmaeil Mohammadbagheri,

Nader Akbari Dilmaghani,

AmirHossein Bayat,

Mobina Fathi,

Kimia Vakili,

Rafieh Alizadeh,

Omidvar Rezaeimirghaed,

Mohammadreza Hajiesmaeili,

Mahtab Ramezani,

Leila Simani,

Abbas Aliaghaei

Publication year - 2020

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.0c00249

Subject(s) - anosmia , proinflammatory cytokine , olfactory epithelium , olfactory mucosa , olfaction , epithelium , cytokine , olfactory system , tumor necrosis factor alpha , respiratory epithelium , medicine , inflammation , immunology , pathology , covid-19 , biology , disease , neuroscience , infectious disease (medical specialty) , psychiatry

Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group ( P < 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct inflammation of the olfactory epithelium could play a role in the acute olfactory loss described in many patients with COVID-19.

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