Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury | Zendy

Nabanita Mukherjee | Zendy; Subhadra Nandi | Zendy; Shubham Garg | Zendy; Satyajit Ghosh | Zendy; Surojit Ghosh | Zendy; Ramkamal Samat | Zendy; Surajit Ghosh | Zendy

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Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury

Author(s) -

Nabanita Mukherjee,

Subhadra Nandi,

Shubham Garg,

Satyajit Ghosh,

Surojit Ghosh,

Ramkamal Samat,

Surajit Ghosh

Publication year - 2020

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.0c00004

Subject(s) - chondroitin sulfate , glial scar , chondroitin sulfate proteoglycan , perineuronal net , inhibitory postsynaptic potential , neuroscience , neurite , regeneration (biology) , spinal cord injury , microbiology and biotechnology , growth cone , chondroitin , chemistry , filopodia , spinal cord , biology , axon , glycosaminoglycan , biochemistry , actin , in vitro

Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar formed after severe traumatic brain injury as well as spinal cord injury and play a crucial inhibitory role in axonal regeneration by selective contraction of filopodia of the growth cone of sprouting neurites. Healing of central nervous system (CNS) injury requires degradation of the glycosamine glycan backbone of CSPGs in order to reduce the inhibitory effect of the CSPG layer. The key focus of this Viewpoint is to address a few important regenerative approaches useful for overcoming the inhibitory barrier caused by chondroitin sulfate proteoglycans.

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