Ionic Strength Sensing in Living Cells | Zendy

Boqun Liu | Zendy; Bert Poolman | Zendy; Arnold J. Boersma | Zendy

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Ionic Strength Sensing in Living Cells

Author(s) -

Boqun Liu,

Bert Poolman,

Arnold J. Boersma

Publication year - 2017

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/acschembio.7b00348

Subject(s) - ionic strength , förster resonance energy transfer , ionic bonding , living cell , biophysics , in vivo , chemistry , nanotechnology , ion , chemical physics , materials science , biology , microbiology and biotechnology , fluorescence , physics , organic chemistry , quantum mechanics , aqueous solution

Knowledge of the ionic strength in cells is required to understand the in vivo biochemistry of the charged biomacromolecules. Here, we present the first sensors to determine the ionic strength in living cells, by designing protein probes based on Förster resonance energy transfer (FRET). These probes allow observation of spatiotemporal changes in the ionic strength on the single-cell level.

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