Artificial Metalloenzymes: Challenges and Opportunities | Zendy

Holly J. Davis | Zendy; Thomas R. Ward | Zendy

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Artificial Metalloenzymes: Challenges and Opportunities

Author(s) -

Holly J. Davis,

Thomas R. Ward

Publication year - 2019

Publication title -

acs central science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.893

H-Index - 76

eISSN - 2374-7951

pISSN - 2374-7943

DOI - 10.1021/acscentsci.9b00397

Subject(s) - nanotechnology , supramolecular chemistry , computer science , scaffold , biomimetic materials , in silico , data science , chemistry , materials science , database , biochemistry , crystal structure , gene , crystallography

Artificial metalloenzymes (ArMs) result from the incorporation of an abiotic metal cofactor within a protein scaffold. From the earliest techniques of transition metals adsorbed on silk fibers, the field of ArMs has expanded dramatically over the past 60 years to encompass a range of reaction classes and inspired approaches: Assembly of the ArMs has taken multiple forms with both covalent and supramolecular anchoring strategies, while the scaffolds have been intuitively selected and evolved, repurposed, or designed in silico . Herein, we discuss some of the most prominent recent examples of ArMs to highlight the challenges and opportunities presented by the field.

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