Open AccessA Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
Author(s) -
Kaid C. Harper,
Eric G. Moschetta,
Shailendra Bordawekar,
Steven J. Wittenberger
Publication year - 2019
Publication title -
acs central science
Language(s) - English
Resource type - Journals
eISSN - 2374-7951
pISSN - 2374-7943
DOI - 10.1021/acscentsci.8b00728
Subject(s) - continuous stirred tank reactor , continuous flow , flow chemistry , photochemistry , chemistry , reactor design , throughput , reactivity (psychology) , catalysis , flow (mathematics) , laser , nanotechnology , process engineering , materials science , computer science , biochemical engineering , organic chemistry , nuclear engineering , mechanics , optics , physics , medicine , telecommunications , alternative medicine , pathology , engineering , wireless
Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.
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