Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides | Zendy

Huiwen Du | Zendy; XiaoYu Hu | Zendy; Hongyang Duan | Zendy; Lanlan Yu | Zendy; Fuyang Qu | Zendy; Qunxing Huang | Zendy; Wangshu Zheng | Zendy; H.-L. Xie | Zendy; Jiaxi Peng | Zendy; Rui Tuo | Zendy; Dan Yu | Zendy; YuChen Lin | Zendy; Wenzhe Li | Zendy; Yongfang Zheng | Zendy; Xiaocui Fang | Zendy; Yimin Zou | Zendy; Huayi Wang | Zendy; Mengting Wang | Zendy; Paul S. Weiss | Zendy; Yanlian Yang | Zendy; Chen Wang | Zendy

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Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides

Author(s) -

Huiwen Du,

XiaoYu Hu,

Hongyang Duan,

Lanlan Yu,

Fuyang Qu,

Qunxing Huang,

Wangshu Zheng,

H.-L. Xie,

Jiaxi Peng,

Rui Tuo,

Dan Yu,

YuChen Lin,

Wenzhe Li,

Yongfang Zheng,

Xiaocui Fang,

Yimin Zou,

Huayi Wang,

Mengting Wang,

Paul S. Weiss,

Yanlian Yang,

Chen Wang

Publication year - 2019

Publication title -

acs central science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.893

H-Index - 76

eISSN - 2374-7951

pISSN - 2374-7943

DOI - 10.1021/acscentsci.8b00723

Subject(s) - oligopeptide , homogeneous , amino acid , computational biology , chemistry , combinatorial chemistry , biochemistry , biology , peptide , statistical physics , physics

We have determined the interaction strengths of the common naturally occurring amino acids using a complete binding affinity matrix of 20 × 20 pairs of homo-octapeptides consisting of the 20 common amino acids between stationary and mobile states. We used a bead-based fluorescence assay for these measurements. The results provide a basis for analyzing specificity, polymorphisms, and selectivity of inter-amino-acid interactions. Comparative analyses of the binding energies, i.e., the free energies of association (Δ G A ), reveal contributions assignable to both main-chain-related and side-chain-related interactions originating from the chemical structures of these 20 common amino acids. Side-chain-side-chain and side-chain-main-chain interactions are found to be pronounced in an identified set of amino acid pairs that determine the basis of inter-amino-acid recognition.

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