Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors | Zendy

Hung V.-T. Nguyen | Zendy; Qixian Chen | Zendy; Joseph T. Paletta | Zendy; P.K. Harvey | Zendy; Yivan Jiang | Zendy; Hui Zhang | Zendy; Michael D. Boska | Zendy; M. Francesca Ottaviani | Zendy; Alan Jasanoff | Zendy; Andrzej Rajca | Zendy; Jeremiah A. Johnson | Zendy

Open Access

Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors

Author(s) -

Hung V.-T. Nguyen,

Qixian Chen,

Joseph T. Paletta,

P.K. Harvey,

Yivan Jiang,

Hui Zhang,

Michael D. Boska,

M. Francesca Ottaviani,

Alan Jasanoff,

Andrzej Rajca,

Jeremiah A. Johnson

Publication year - 2017

Publication title -

acs central science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.893

H-Index - 76

eISSN - 2374-7951

pISSN - 2374-7943

DOI - 10.1021/acscentsci.7b00253

Subject(s) - nitroxide mediated radical polymerization , magnetic resonance imaging , in vivo , nuclear magnetic resonance , contrast (vision) , chemistry , materials science , nanotechnology , medicine , polymer , radiology , computer science , biology , physics , radical polymerization , microbiology and biotechnology , artificial intelligence , copolymer

Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI in vivo . Herein, we report nitroxide-functionalized brush-arm star polymer organic radical contrast agents (BASP-ORCAs) that overcome the low contrast and poor in vivo stability associated with nitroxide-based MRI contrast agents. As a consequence of their unique nanoarchitectures, BASP-ORCAs possess per-nitroxide transverse relaxivities up to ∼44-fold greater than common nitroxides, exceptional stability in highly reducing environments, and low toxicity. These features combine to provide for accumulation of a sufficient concentration of BASP-ORCA in murine subcutaneous tumors up to 20 h following systemic administration such that MRI contrast on par with metal-based agents is observed. BASP-ORCAs are, to our knowledge, the first nitroxide MRI contrast agents capable of tumor imaging over long time periods using clinical high-field 1 H MRI techniques.

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