18F-Deoxyfluorination of Phenols via Ru π-Complexes | Zendy

M. Hassan Beyzavi | Zendy; Debashis Mandal | Zendy; Martin G. Strebl | Zendy; Constanze N. Neumann | Zendy; Erica M. D’Amato | Zendy; Junting Chen | Zendy; Jacob M. Hooker | Zendy; Tobias Ritter | Zendy

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¹⁸F-Deoxyfluorination of Phenols via Ru π-Complexes

Author(s) -

M. Hassan Beyzavi,

Debashis Mandal,

Martin G. Strebl,

Constanze N. Neumann,

Erica M. D’Amato,

Junting Chen,

Jacob M. Hooker,

Tobias Ritter

Publication year - 2017

Publication title -

acs central science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.893

H-Index - 76

eISSN - 2374-7951

pISSN - 2374-7943

DOI - 10.1021/acscentsci.7b00195

Subject(s) - phenols , bottleneck , scope (computer science) , positron emission tomography , substrate (aquarium) , moisture , chemistry , computer science , radiochemistry , materials science , nanotechnology , combinatorial chemistry , environmental science , organic chemistry , nuclear medicine , geology , embedded system , medicine , oceanography , programming language

The deficiency of robust and practical methods for 18 F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18 F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

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