Open AccessA Continuing Career in Biocatalysis: Frances H. Arnold
Author(s) -
Rudi Fasan,
S. B. Jennifer Kan,
Huimin Zhao
Publication year - 2019
Publication title -
acs catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.898
H-Index - 198
ISSN - 2155-5435
DOI - 10.1021/acscatal.9b02737
Subject(s) - biocatalysis , honor , directed evolution , chemistry , biochemical engineering , nanotechnology , computer science , engineering , catalysis , organic chemistry , materials science , biochemistry , reaction mechanism , mutant , gene , operating system
On the occasion of Professor Frances H. Arnold's recent acceptance of the 2018 Nobel Prize in Chemistry, we honor her numerous contributions to the fields of directed evolution and biocatalysis. Arnold pioneered the development of directed evolution methods for engineering enzymes as biocatalysts. Her highly interdisciplinary research has provided a ground not only for understanding the mechanisms of enzyme evolution but also for developing commercially viable enzyme biocatalysts and biocatalytic processes. In this Account, we highlight some of her notable contributions in the past three decades in the development of foundational directed evolution methods and their applications in the design and engineering of enzymes with desired functions for biocatalysis. Her work has created a paradigm shift in the broad catalysis field.