Iron-Catalyzed Borrowing Hydrogen β-C(sp3)-Methylation of Alcohols | Zendy

Kurt Polidano | Zendy; Jonathan M. J. Williams | Zendy; Louis C. Morrill | Zendy

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Iron-Catalyzed Borrowing Hydrogen β-C(sp³)-Methylation of Alcohols

Author(s) -

Kurt Polidano,

Jonathan M. J. Williams,

Louis C. Morrill

Publication year - 2019

Publication title -

acs catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.898

H-Index - 198

ISSN - 2155-5435

DOI - 10.1021/acscatal.9b02461

Subject(s) - catalysis , methanol , methylation , yield (engineering) , chemistry , hydrogen , medicinal chemistry , organic chemistry , materials science , biochemistry , metallurgy , gene

Herein we report the iron-catalyzed β-C (sp 3 )-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C (sp 3 )-methylation in good isolated yields (24 examples, 65% average yield).

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