Open AccessN-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations
Author(s) -
Laura Scalvini,
Andrea Ghidini,
Alessio Lodola,
Donatella Callegari,
Silvia Rivara,
Daniele Piomelli,
Marco Mor
Publication year - 2020
Publication title -
acs catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.898
H-Index - 198
ISSN - 2155-5435
DOI - 10.1021/acscatal.0c02903
Subject(s) - amidase , chemistry , palmitoylethanolamide , qm/mm , acylation , nucleophile , hydrolysis , leaving group , active site , stereochemistry , molecular dynamics , catalysis , organic chemistry , computational chemistry , biochemistry , receptor , cannabinoid receptor , agonist
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