Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions | Zendy

Bo Yuan | Zendy; Durga Mahor | Zendy; Qiang Fei | Zendy; Ron Wever | Zendy; Miguel Alcalde | Zendy; Wuyuan Zhang | Zendy; Frank Hollmann | Zendy

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Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions

Author(s) -

Bo Yuan,

Durga Mahor,

Qiang Fei,

Ron Wever,

Miguel Alcalde,

Wuyuan Zhang,

Frank Hollmann

Publication year - 2020

Publication title -

acs catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.898

H-Index - 198

ISSN - 2155-5435

DOI - 10.1021/acscatal.0c01958

Subject(s) - halogenation , chemistry , hydroxylation , catalysis , methanol , anthraquinone , organic chemistry , combinatorial chemistry , redox , enzyme

Peroxyzymes simply use H 2 O 2 as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H 2 O 2 can be addressed by a controlled supply of H 2 O 2 , ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H 2 O 2 generation. Very promising turnover numbers for the biocatalysts of up to 318 000 have been achieved.

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