Enhanced Differentiation of Human Preosteoblasts on Electrospun Blend Fiber Mats of Polydioxanone and Anionic Sulfated Polysaccharides | Zendy

Nowsheen Goonoo | Zendy; Archana BhawLuximon | Zendy; Ulrich Jonas | Zendy; Dhanjay Jhurry | Zendy; Holger Schönherr | Zendy

Open Access

Enhanced Differentiation of Human Preosteoblasts on Electrospun Blend Fiber Mats of Polydioxanone and Anionic Sulfated Polysaccharides

Author(s) -

Nowsheen Goonoo,

Archana BhawLuximon,

Ulrich Jonas,

Dhanjay Jhurry,

Holger Schönherr

Publication year - 2017

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.7b00350

Subject(s) - fucoidan , nanofiber , viability assay , polysaccharide , materials science , miscibility , fiber , chemistry , chemical engineering , nanotechnology , organic chemistry , biochemistry , cell , polymer , engineering

The viability and differentiation of SaOS-2 preosteoblasts on fiber mats of blends comprising of the biodegradable poly(ester-ether) polydioxanone (PDX) and the sulfate-containing anionic polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) were investigated for a range of different blend compositions. The detailed analysis of the blend nanofiber properties revealed a different degree of miscibility of PDX and the polysaccharide leading to a different enrichment at the surface of the blend nanofibers, which were observed to be stable in phosphate buffer solution (PBS) for up to 5 weeks. The fibrous mats of PDX/FUC led to the highest osteogenic differentiation with very good cell viability. The electrospun blend fibers also supported human-induced pluripotent stem (iPS) cells and iPS cell-derived embryoid bodies with high cell viability, which underlines the potential of these novel blend fiber systems for optimized performance in bone tissue engineering applications.

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