3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening | Zendy

Haibin Guo | Zendy; Nan Deng | Zendy; Lei Dou | Zendy; Huifen Ding | Zendy; Tracy Criswell | Zendy; Anthony Atala | Zendy; Cristina M. Furdui | Zendy; Yuanyuan Zhang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening

Author(s) -

Haibin Guo,

Nan Deng,

Lei Dou,

Huifen Ding,

Tracy Criswell,

Anthony Atala,

Cristina M. Furdui,

Yuanyuan Zhang

Publication year - 2020

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.0c01468

Subject(s) - nephrotoxicity , organoid , stem cell , kidney , extracellular matrix , cell culture , renal stem cell , microbiology and biotechnology , biology , chemistry , progenitor cell , endocrinology , genetics

The development of human cell-based systems to replace the use of rodents or the two-dimensional culture of cells for studying nephrotoxicity is urgently needed. Human urine-derived stem cells were differentiated into renal tubular epithelial cells in three-dimensional (3-D) culture after being induced by a kidney extracellular matrix. Levels of CYP2E1 and KIM-1 in 3-D organoids were significantly increased in response to acetone and cisplatin. This 3-D culture system provides an alternative tool for nephrotoxicity screening and research.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research