Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicans Growth and Reduce the Biofilm Viability | Zendy

Katharina H. Clitherow | Zendy; Tahani M. Binaljadm | Zendy; J. Mølholm Hansen | Zendy; Sebastian G. Spain | Zendy; Paul V. Hatton | Zendy; Craig Murdoch | Zendy

Open Access

Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicans Growth and Reduce the Biofilm Viability

Author(s) -

Katharina H. Clitherow,

Tahani M. Binaljadm,

J. Mølholm Hansen,

Sebastian G. Spain,

Paul V. Hatton,

Craig Murdoch

Publication year - 2020

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.0c00614

Subject(s) - candida albicans , biofilm , microbiology and biotechnology , corpus albicans , candida tropicalis , nystatin , chemistry , agar diffusion test , polycaprolactone , drug delivery , agar , antimicrobial , antifungal drug , biology , antifungal , bacteria , biochemistry , organic chemistry , genetics , escherichia coli , gene , polymer

Oral candidiasis is a very common oral condition among susceptible individuals, with the main causative organism being the fungus Candida albicans . Current drug delivery systems to the oral mucosa are often ineffective because of short drug/tissue contact times as well as increased prevalence of drug-resistant Candida strains. We evaluated the potency of saturated fatty acids as antifungal agents and investigated their delivery by novel electrospun mucoadhesive oral patches using agar disk diffusion and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the most effective at inhibiting C. albicans growth on disk diffusion assays, both in solution or when released from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100) electrospun patches. In contrast, dodecanoic acid (C12) displayed the most potent antifungal activity against pre-existing C. albicans biofilms in solution or when released by PCL or PVP/RS100 patches. Both free and patch-released saturated fatty acids displayed a significant toxicity to wild-type and azole-resistant strains of C. albicans . These data not only provide evidence that certain saturated fatty acids have the potential to be used as antifungal agents but also demonstrate that this therapy could be delivered directly to Candida -infected sites using electrospun mucoadhesive patches, demonstrating a potential new therapeutic approach to treat oral thrush.

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