Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores | Zendy

Subhasish Sahoo | Zendy; Jawad Ur Rehman | Zendy; Muhammad Raza Shah | Zendy; Priyadarsi De | Zendy; Paolo Tecilla | Zendy

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Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores

Author(s) -

Subhasish Sahoo,

Jawad Ur Rehman,

Muhammad Raza Shah,

Priyadarsi De,

Paolo Tecilla

Publication year - 2021

Publication title -

acs applied polymer materials

Language(s) - English

Resource type - Journals

ISSN - 2637-6105

DOI - 10.1021/acsapm.0c01182

Subject(s) - cholic acid , copolymer , amphiphile , monomer , polymer chemistry , chemistry , moiety , polyethylene glycol , ether , polymer , methacrylate , liposome , conjugated system , membrane , methyl methacrylate , organic chemistry , bile acid , biochemistry

A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H + , Na + ) and of large polar organic molecules (calcein). Their activity is strictly correlated to the content of cholic acid subunits, increasing as the fraction of cholate moiety increases.

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